WebJan 23, 2024 · PURPOSE Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatments. Delta-like ligand 3 (DLL3) is aberrantly expressed in most SCLC. Tarlatamab (AMG 757), a bispecific T-cell engager molecule, binds both DLL3 and CD3 leading to T-cell–mediated tumor lysis. Herein, we report phase I results of tarlatamab in … WebTarlatamab [WHO-DD] Source: Common Name English AMG757: Source: Code English Classification Tree Code System Code; FDA ORPHAN DRUG 665418. Created by admin on Sun Dec 18 13:15:20 UTC 2024, Edited by admin on Sun Dec 18 13:15:20 UTC 2024. Code System Code Type Description; FDA UNII: 74X82ST8Q1 ...
AMGEN PRESENTS NEW TARLATAMAB CLINICAL DATA AT WCLC 2024
WebJan 23, 2024 · Tarlatamab, a half-life extended bispecific T-cell engager (HLE BiTE) molecule, binds both DLL3 on cancer cells and CD3 on T cells leading to T-cell–mediated tumor lysis. Tarlatamab promotes tumor … WebAug 8, 2024 · Tarlatamab is being investigated in multiple studies, including DeLLphi-301, a potentially registrational Phase 2 study in relapsed/refractory SCLC; DeLLphi-303, a Phase 1b study testing ... gradle local repository path
AMGEN OUTLINES GROWTH STRATEGY THROUGH 2030 AT …
WebAug 4, 2024 · Tarlatamab (AMG 757) Updated exploration and first expansion Phase 1 data of tarlatamab, a half-life extended (HLE) bi-specific T-cell engager (BiTE ®) molecule targeting delta-like ligand 3 (DLL3), in heavily pretreated patients with relapsed/refractory small cell lung cancer (SCLC) will be presented on Aug 8th at WCLC. In this setting ... WebMar 1, 2024 · AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer AMG 757 has a compelling safety and efficacy profile in preclinical studies making it a viable option for targeting DLL3-expressing SCLC tumors in the clinical setting. WebJun 2, 2024 · Tarlatamab is an HLE BiTE immuno-oncology therapy designed to bind DLL3 on target cancer cells and CD3 on T cells, forming a cytolytic synapse inducing T cell … gradle maven-publish plain