WebFeb 1, 2008 · The photogenotoxicity of five common drugs (sparfloxacin, dacarbazine, chlorpromazine and 8-methoxypsoralen, promazine) was investigated in the skin as well as in the retina and cornea of Wistar rats. The compounds were administered once orally by gavage and the resulting DNA damage was analyzed in the newly developed in vivo photo … WebPhototoxicity is a toxic response from a substance applied to the body which is either …
Phototoxicity and photoallergy - PubMed
Webphotoirritation, photoallergy, and photogenotoxicity could be evaluated by ROS assay. ROS … WebMar 1, 2003 · However, photogenotoxicity cannot totally be excluded, since, in spite of the low quantum yield for generation of 1 O 2 , different modes of action not involving singlet oxygen are a possibility ... soho station birmingham
Phototoxicity PETA
WebMar 1, 2012 · The differences in phototoxicity and photogenotoxicity found may reflect differences in cellular uptake, distribution and metabolism. However, the specific tendency of a furocoumarin congener to intercalate into the DNA ( Musajo and Rodighiero, 1972 ), and its local photoreactivity within the DNA ( Isaacs et al., 1984 ) appear to be likely ... WebJun 1, 2024 · It causes damage to human keratinocytes (phototoxicity, photogenotoxicity, membrane damage, depolarization of organelles). This is the first study to elucidate the mechanism of NB phototoxicity and photogenotoxicity under sunlight exposure and correlate the effect of ambient environmental intensities with artificial UV irradiation. WebNov 1, 2010 · In terms of photogenotoxicity testing, the main objective is an assessment of the potential of a compound to be converted into a chemical species that may elicit a carcinogenic effect upon activation with UV or visible ( sic solar simulated) radiation. Several in vitro photogenotoxicity assays, such as the photo-Ames, photo-chromosome ... soho stationery at international plaza