CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. Overexpression of CTGF in fibroblasts promotes … See more CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. Ctgf-null mice also show defects in … See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more WebJun 4, 2015 · These findings are coupled to significant reductions in p57 Kip2 and phosphorylated SMAD2/3 in HSCs, suggesting that MUSASHI-2 modulates the TGF-β signaling circuitry. 43 Most work regarding TGF-β in hematopoiesis has focused on TGF-β1. However, TGF-β exists in 3 isoforms that are encoded by separate genes, Tgfb1-3.
What is the role of TGF-beta in wound healing? ResearchGate
WebDec 25, 2024 · tgf-β 通过多种机制实现其肿瘤促进作用。例如,tgf-β 通过抑制一些免疫细胞,如 t 细胞的增殖和功能实现免疫抑制;tgf-β 诱导分泌结缔组织生长因子 (ctgf)、内皮素-1 和血管内皮生长因子 (vegf) 的分泌,促进血管、肿瘤纤维间质的形成。 WebOct 28, 2024 · Then, phosphorylated Smad2/3 translocates into the nuclei from the cytosol and functions as transcription factors that induce the expression of multiple fibrotic genes, including CTGF, TGF-β, and plasminogen activator inhibitor-1 (PAI-1) [7,9]. During the above-mentioned process, p53 is required for Smad2/3 nuclear translocation. can melatonin make it hard to wake up
尘肺患者血清 TGF-β,PDGF 含量分析-曲莉王洪艳陶凌-中文期刊【 …
WebIn our results, TGF-β1 significantly increased STAT3 phosphorylation and p-STAT3 translocation to the nucleus. Moreover, TGF-β1 increased the expressions of MMP-2, … WebIn general, the TGF-β/1L-10-mediated, anti-inflammatory alloreactive mechanisms can be considered as surrogate markers for the development of a nonaggressive immune … WebJul 4, 2024 · CTGF has been reported to bind to TGF-β through the N-terminal von 24 Willebrand factor domain, and this has been suggested to augment TGF- β activity, 25 potentiating fibrosis (21). fixed money market